Select statements that accurately describe receptor tyrosine kinases (RTKs).

a) The intracellular domain has phosphatase domains.
b) Some RTKs are dimeric in the presence of a ligand.
c) Ligand binding is required for autophosphorylation (cross‑phosphorylation).
d) The structure includes a transmembrane helix.
e) The α subunit contains seven α helices that span the membrane.
f) A ligand binds to the extracellular domain.

B,C,D,F

Explanation:

Of the given propositions it is correct that:

B. RTKs are generally (but not always) monomeric in the absence of ligand.

The observed structure of most RTKs are monomeric, thus their structure will adapt to the needs of the organism

C. A ligand binds to the extracellular domain.

When the cell can express extracellular domains, many of the ligands that circulate through the medium will be able to find their targets and trigger reactions.

D. Ligand binding is required for autophosphorylation (cross phosphorylation).

After the ligand finds its domain, the union will generate conformational changes, including autophosphorylation. which will produce chain reaction

F. The structure includes a transmembrane helix.

it is true that the membrane has a propeller that allows its conformation

it takes hundreds of years to become stable.

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