Choose the true statements about amyloid fibrils. 3 options are correct:a) An amyloid fibril typically forms from aggregates of misfolded peptides resulting from frameshift mutations. b) An amyloid fibril is stabilized by hydrophobic interactions between aromatic residues. c) Soluble proteins that misfold and form amyloid fibrils become insoluble. d) Because most newly synthesized proteins fold correctly, the accumulation of misfolded proteins (or fragments) tends to occur slowly, thus explaining the slow onset of disease. e) Proteins that convert to an amyloid fibril structure tend to have low solubility in their native form.

The correct answers are: b) "An amyloid fibril is stabilized by hydrophobic interactions between aromatic residues", c) "Soluble proteins that misfold and form amyloid fibrils become insoluble", and d) "Because most newly synthesized proteins fold correctly, the accumulation of misfolded proteins (or fragments) tends to occur slowly, thus explaining the slow onset of disease".

Explanation:

Amyloid fibrils are protein aggregates that can cause pathological conditions, for instance, they are found in brain tissue in people with Alzheimer disease. This disease, and other relates diseases, have a slow onset because most newly synthesized proteins fold correctly and the protein aggregates are made up misfolded proteins. This newly synthesized proteins are soluble, but once the proteins are misfolded, they form amyloid fibrils that are insoluble. The amyloid fibrils are stabilized by hydrophobic interactions between aromatic residues, which are formed within the complex of insoluble misfolded proteins.

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