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osteogenesis imperfecta (oi) refers to a congenital ailment of bones. in the condition, the bones become brittle or fragile. this ailment is a general result of the defect or mutations in the genes (colia1 or colia2). this mutation results in imperfect collagen formation either in quantity or quality wise.  

there are eight kinds of oi defects, and each kind varies with certain distinctions in symptoms. the usual symptoms include frequent bone fractures, loss of hearing in infants, protruding eyes, discoloration of the white in the eyes, respiratory issues, loosening of the joints, short stature, and other symptoms.  

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the calvin cycle takes place in the stroma of the chloroplast. carbon dioxide enters the stroma of the chloroplast to combine with the five-carbon compound called ribulose1, 5-biphosphate to form two molecules of a three-carbon compound called 3-phosphoglyceric acid. this reaction is catalyzed by an enzyme called ribulose bi-phosphate carboxylase.