Using the techniques of genetic engineering, you design a protein you want to accumulate within the ER of yeast cells. To accomplish this goal, you need to Using the techniques of genetic engineering, you design a protein you want to accumulate within the ER of yeast cells. To accomplish this goal, you need to do nothing; all proteins go through the ER. incorporate radioactive amino acids into the protein. remove the N-formyl group located at the N-terminus of the polypeptide. incorporate appropriate mannose-6-phosphate groups. incorporate the appropriate DNA sequence(s) to create signal sequences in the mature peptide.