Club foot is a rare disease due to congenital skeletal abnormalities, both genetic and nongenetic factors are thought to be responsible for club foot. A family in which club foot was inherited as an autosomal dominant trait with reduced penetrance was identified in 2008. It was found that a mutation in the PITXI gene that caused club foot in this family. Through DNA testing, they determined that 11 people in the family carried the PITXI mutation, but only 8 of these people had club foot. Required:
What is the penetrance of the PIXTI mutation in this family?

72.72%

Explanation:

The Penetrance of the PIXTI mutation in this family can be represented as

The Penetrance represents the percentage of people who show/have the disease

family size = 11

number of people with the disease = 8

Penetrance of PIXTI in the family can be calculated as  = 8/11 * 100

                   = 0.7272  * 100

                   = 72.72%

The remaining 27.38 % are just carriers of the PITXI gene

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why many students visually perceive stem as a vapid class?

for many students, however, stem subjects are optically discerned as vapid, tedious, and destitute of authentic-world applications. science and math have always been a major part of the high school curriculum, but many students have disengaged from these subjects because they don’t optically discern that they have any pertinence to the authentic world or students’ daily lives. for them, math and science have become a set of rules, procedures, laws, theorems, and formulas to memorize. some students even develop math apprehensiveness and cerebrate they are incapable of learning higher-level mathematics.

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as the u.s. economy changes, the ordinant dictation for stem-capable workers is growing. in may of 2014, the u.s. bureau of labor statistics counted more than 8.3 million stem jobs, which accounted for 6.2 percent of total employment in the cumulated states. that number is expected to perpetuate to increment as u.s. companies grow and innovate to compete in the ecumenical economy. according to the u.s. department of labor, the average salary for all stem jobs is $85,570, which is virtually double the average salary for all jobs.

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