In the 1960s the molecular biology George Streisinger developed the strand-slippage hypothesis. Streisinger noticed that mutations occurred in areas of DNA that contained many repeated sequences. When a strand-slippage error occurs, an insertion mutation can result. How does the insertion mutation affect the DNA? a Nitrogenous bases are added b Nitrogenous bases are damaged. c Nitrogenous bases are exchanged. d Nitrogenous bas

a Nitrogenous bases are added

Explanation:

George Streisinger used a bacterial virus (phage T4) to show that most insertions and deletions (indels) are due to mutations in tandem repeats. From this discovery, Streisinger proposed the strand-slippage hypothesis, which enabled to understand this process. The strand-slippage hypothesis indicates that slipped strand mispairing mutations during DNA replication may be due to DNA loops which are associated with the incorrect insertion/deletion of a nucleotide to the newly synthesized strand, and these indels can become permanent mutations.

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