Lucy and Jim have been married for 5 years and have decided they would like to try to have a child. However, a rare genetic disorder runs in both or their families, so they decide to go to a genetic counselor to determine the chances that their future child will be affected. The disease achondrogenesis 1a affects the ability of proteins necessary for bone and cartilage development to be modified and packaged properly after leaving the endoplasmic reticulum. The results are devastating. Individuals with this disorder are often stillborn or die soon after birth from respiratory failure. Fortunately, after doing a genetic screening, the genetic counselor determined that while Jim is a carrier for this autosomal recessive disorder, Lucy is not. Therefore, if they do have a child it is unlikely that their child will be affected. Which organelle has been compromised

The Golgi complex is compromised      

Explanation:  

The Golgi complex helps in the process of synthesis and packaging of proteins and lipids, especially those proteins that are for exportation. The organelle´s function is to manage the recently synthesized proteins, to transform them, and to export them to other places.

Different proteins are synthesized in the endoplasmic reticulum and sent to the Golgi complex in vesicles, where it happens the final association of carbohydrates with proteins. Finally, protein is transported from the Golgi complex to its final destiny. Proteins destined to a certain place are packaged all together in the same vesicle and sent to the target organ. In the case of membrane proteins, they are packaged in vesicles and sent to the cell membrane where they get incrusted.

By being affected by the achondrogenesis 1a, the Golgi complex loses its functions and is incapable of finishing the protein synthesis and transport process, affecting other cells and their functions.  

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