Students are asked to analyze the diagram below and identify the type mutation that causes sickle-cell anemia (red blood cell disorder). Which of the following students correctly identifies the mutation that causes the disorder?
Wild-type haemoglobin DNA
Mutant haemoglobin DNA
3
5
3
5
mRNA
mRNA
G
5
5
Normal haemoglobin
Glu
Sickle cell haemoglobin
Val
O A Student 3 claims that sickle-cell anemia is caused by a substitution mutation. The "T" nucleotide in the DNA is removed.
OB. Student 4 claims that sickle-cell anemia is caused by a substitution mutation. The 'T nucleotide in the DNA is replaced by a different nucleotide
O C. Student 1 claims that sickle-cell anemia is caused by a deletion mutation. The T nucleotide in the DNA is removed.
O D. Student 2 claims that sickle-cell anemia is caused by a deletion mutation. The 'T nucleotide in the DNA is replaced by a different nucleotide.