Generalizations, explanations of natural phenomena, and additional hypotheses most often come about as a result of

i believe the correct answer from the choices listed above is the first option. the scientists need to look at the   validity of data, claims, hypotheses, and observations before  developing an argument. they base their arguments on facts that are present and they make sure they have proofs. 

explanation:

the menstrual cycle – higher tier. negative feedback mechanisms affect the production of hormones in the menstrual cycle. oestrogen also stimulates the release of lh (luteinising hormone) from the pituitary gland, which in turn controls the production of progesterone.