Which of the following best describes the role IkBa phosphorylation plays in the signaling pathway and what the modification of IkB, does?
IkB, activates the transcription factor. Phosphorylation of IkB, leads to phosphorylation and activation of the
transcription factor.
O IKB, inhibits the activation of the transcription factor. Phosphorylation of IKB, signals for the nuclear transcription
factor to transcribe DNA.
O IKB, inhibits the translocation of the transcription factor. Phosphorylation of IkB, signals for IkB, degradation
and allows the transcription factor to enter the nucleus.
O IkB, activates the translocation of the transcription factor. Phosphorylation of IKB, leads to phosphorylation of
the transcription factor, which allows the transcription factor to enter the nucleus.