Please help w my bio hw! Some inherited diseases, including LCA, may be caused by mutations in a single gene. Pedigrees can be used to
determine the patterns of inheritance for these diseases.
In a 1998 study, scientists analyzed a series of pedigrees showing the family histories of LCA patients. Some of
their pedigrees are shown in the following figures. Squares represent males, circles represent females, and
shading indicates that an individual has LCA.
IT
Figure 1. A pedigree of a family that has individuals
with LCA. Adapted from Morimura et al. (1998).
Figure 2. Two pedigrees of families that have individuals
with LCA. Adapted from Morimura et al. (1998).

2. Based only on the pedigree in Figure 1, can you determine whether LCA is or isn't inherited according to an
autosomal dominant, autosomal recessive, or X-linked recessive pattern? Explain your answer.

3. Based on the pedigrees in Figure 2, can you determine whether LCA is or isn't inherited according to an
autosomal dominant, autosomal recessive, or X-linked recessive pattern? Explain your answer.