Glycogen synthetase kinase 3 beta is a protein kinase that has been implicated in many types of cancer. Depending on the cell type, the gene for glycogen synthetase kinase 3 beta (GSK38) can act ether as an oncogene or as a tumor suppressor. Which of the following best predicts how GSK 98 mutations can lead to the development of cancer? A Cells with inactive GSK 38 fail to trigger apoptosis. B Cells with inactive GSK 38 fail to proceed past the G2/M checkpoint. с Cells with overactive GSK 98 are more likely to repair DNA damage. Cells with overactive GSK 38 have longer cell cycles.

A Cells with inactive GSK 38 fail to trigger apoptosis

Explanation:

Apoptosis is defined as the process of programmed death cell. Tumor cells are capable of evading apoptosis, thereby leading to uncontrolled cell proliferation. Glycogen synthase kinase 3 (GSK-3) is a protein kinase that phosphorylates serine and threonine amino acid residues on different substrates, thus activating different signaling pathways and having different biological functions. The GSK-3-mediated phosphorylation on different substrates may lead to the activation or inactivation of apoptosis depending on the cell type. Thus, GSK-3 has a dual activity and functions as a tumor suppressor and oncoprotein.

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