Doctor Kryskowski: In this family a young man is affected with an X-linked recessive disorder. In these disorders we often see more affected men
than women, as a man with a mutation on his X chromosome will be
affected, whereas a woman heterozygous for the mutation will be an
unaffected carrier. In this case the mother of the young man must be a
heterozygous carrier of the disease, as he has inherited his X
chromosome with the mutation from her. What is the risk that the man's
sibling (indicated 2) and child (indicated 1) will develop the disease,
provided that the man's wife is not a carrier?
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d. in sexual reproduction, offspring have more chromosomes than

either parent.

asexual reproduction results in offspring which are genetically the same as the parent organism (not counting a rare mutation). sexual reproduction produces a random mixture of the genetics derived from both parents

explanation:

an individual’s sex (i.e., whether they are a male or female) is determined by the sex chromosomes. most people have two sex chromosomes, one that is inherited from their mother and one that is inherited from their father. typically, females have two x chromosomes (xx) and males have one x chromosome and one y chromosome (xy). conditions caused by changes (“mutations”) in genes located on the x chromosome are considered x-linked.

x-linked recessive inheritance

most x-linked conditions are recessive. this means that in a person with two x chromosomes (most females), both copies of a gene (i.e., one on each x chromosome) must have a change or mutation whereas in a person with one x chromosome (most males), only one copy of a gene must have a mutation. a female with a mutation in one copy of a gene on the x chromosome is said to be a “carrier” for an x-linked condition. a male with a mutation in a gene on the x chromosome is typically affected with the condition. because females have two copies of the x chromosome and males have only one x chromosome, x-linked recessive diseases are more common among males than females. however, x-linked recessive diseases can occur in both males and females.

for x-linked recessive disorders, an unaffected carrier mother who has a mutation in a gene on the x chromosome can transmit either the x chromosome with this mutation or a “normal” x chromosome to her children. if the father is unaffected, none of her daughters will be affected and all of her daughters will be unaffected—since they will inherit at least one normal x chromosome from their father. however, each daughter will have a 50% chance of being an unaffected carrier like her mother and a 50% chance of both x chromosomes being normal.

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