Synthetic biologists at the Scripps Institute expanded the genetic repertoire by adding two new bases into living bacterial cells. The two bases are named d5SICS and dNaM, and they base-pair with one another. How many different codons are possible in nucleic acids containing six different nucleotides if a codon consists of a consecutive sequence of three nucleotides

216 codons

Explanation:

In the RNA molecule there are four types of nucleotide bases, i.e., Adenine, Uracil (Thymine in DNA), Guanine, and Cytosine. In consequence, the number of possible codons or combinations of nucleotide triplets is 64 (4³ = 64 codons). However, these 64 codons code for only 20 different amino acids because multiple codons can code for the same amino acid, it is for that reason that the genetic code is redundant. In this case, if the number of bases would be six (6) instead of four (4) bases, then the number of possible combinations of nucleotide triplets would be 216 codons (6³ = 216).

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