What factor most affects whether a mutation will be passed to offspring?
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Mutation, an alteration in the genetic material (the genome) of a cell of a living organism or of a virus that is more or less permanent and that can be transmitted to the cell’s or the virus’s descendants. The genomes of organisms are all composed of DNA, whereas viral genomes can be of DNA or RNA.

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Mutations are only passed on to offspring when they occur in germ cell DNA, which are the cells that create sperm or ova. ... The mutation will be inherited only if it occurred on a chromosome in either the sperm cell or the ova cell out of many that eventually unite to form a zygote.

They are present in all body cells and can be passed down to new generations. Acquired mutations occur during an individual's life. If an acquired mutation occurs in an egg or sperm cell, it can be passed down to the individual's offspring. Once an acquired mutation is passed down, it is a hereditary mutation

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americans began to notice growing differences between the northern and southern sections of the country. there were more people living in cities in the north, which made it more urban. more people lived on farms in the south, which made it more rural. while many people were farmers in the northern states, there were now other ways to make a living, such as working in mechanical cotton gins factories manufacturing cloth, tools and other goods. people in the north supported high tariffs on goods imported from europe because the extra cost encouraged people to “buy american” instead. in the southern states, planters did not like tariffs because they sold most of their production to europe and bought their tools from there as well. southerners believed the protective tariff was something that only northern factory owners keep their profits high. so the southern politicians came up with an idea. they would opt out. they would simply ignore the protective tariff. it was ‘null and void’ in south carolina. the state would not collect the taxes on goods imported into south carolina, no matter what the president said they had to do. this decision led to the nullification crisis.

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