Why would it not make sense for the cell to wait to combine Okazaki fragments into one continuous lagging strand until the entire DNA molecule has been replicated

Okazaki fragments are short DNA nucleotides sequences that are formed discontinuously and then combine into one continuous lagging strand with the help of DNA ligase, the endonuclease, and polymerase. It takes place before the entire DNA molecule has been replicated.

If the cell waited to combine Okazaki fragments until the entire DNA molecule had been replicated then the newly synthesized lagging strand that are still Okazaki fragments might already be packaged and inaccessible to the all essential enzymes that are ligase, polymerase, and endonuclease that help to generate a continuous leading strand.

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explanation:

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during the process of dna replication, brdu can replace thymidine and incorporate into the newly synthesized dna, cell proliferation thus can be reflected in the extent of brdu incorporation.