In grapes, the wild-type DND1 gene confers resistance to attain viruses, and strains are susceptible to viruses. The EDS1 gene confers resistance to powdery mildew, a type of fungal infection. The genes are linked, eight map units apart on chromosome 17. A third gene, IR 1. imparts resistance to certain lepidopteran leafminers and is 10 map units from EDS1 and 18 map units from UNDI The abserved double crossover rate is 0.3%. What is the interference? a. 37.5%
b. 25.%
c. 62.5%
d. 75%

I = 62.5%

Explanation:

Available data:

According to this information, we can picture the position of each gene in the chromosome

---DND1EDS1IR1---

       ║ 8MU║10MU║

       ║18MU║

The map unit is the distance between the pair of genes for which one of every 100 meiotic products results in a recombinant product.

1% of recombinations = 1 map unit = 1cM. The maximum recombination frequency is always 50%.

So, if we know the distances between genes, we know their recombination percentages.

To calculate interference, first, we need to know the coefficient of coincidence, CC.    

CC= observed double recombinant frequency/expected double recombinant frequency

Note:

CC= (0.003)/(0.08 x 0.1)

CC=0.003/0.008

CC=0.375

CC = 37.5%

The coefficient of interference, I, is complementary with CC.

I = 1 - CC

I = 1 - 0.375

I = 0.625

I = 62.5%

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