Why is the timing of a mutation in relation to fertilization important in whether it can be passed onto offspring?

Please give me brainlist

Explanation:

Macbeth's character changes a great deal over the course of the play. At the beginning of the play, Macbeth is a respected Thane who has shown great loyalty to King Duncan. Soon after, Macbeth succumbs to ambition and, encouraged by a prophecy and Lady Macbeth, murders King Duncan to take his throne.

1. dermis

2. chemical

3. urine

4. viruses

5. antibodies

i would say it is