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Histone proteins are among the most highly conserved protein in eukaryotes. Histone H4 proteins from a pea and a cow, for example, differ in only 2 of 102 amino acids. However, comparison of the two gene (nucleotide) sequences shows many more differences. These observations indicate that mutations that change amino acids must be selected against.
Required:
Why do you suppose that amino acid-altering mutations in histone genes are deleterious?
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Histone proteins are among the most highly conserved protein in eukaryotes. Histone H4 proteins from...
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