3. The presence of Malaria in many countries has been eradicated and even in parts of Africa, the incidence of Malaria has been reduced substantially. Without endemic malaria from Africa, the sickle cell mutation is purely disadvantageous. What do you think will happen to the percentage of people carrying the Sickle Cell gene over time under the pressures of natural selection

The percentage of people carrying sickle cell gene increases.

Explanation:

People carrying the Sickle Cell gene have low chance of Malaria because the sickle cell enables the body to detoxify abnormal red blood cells from the body. When the malarial parasite attacks on the cells of the body, the molecular machinery for cleaning up the waste is already present in the body.  Those places where malaria is common, the people having sickle cell because the sickle cell show resistance against malarial disease.