Which of the following causes epigenetic modifications to DNA that affect gene expression without changing the DNA sequence? Base-pair substitution
DNA methylation
Mutation in regulatory sites
Gene knockout

homeostasis is the tendency towards a relatively stable equilibrium between interdependent elements, especially as maintained by physiological processes. and this is how it applies to the integumentary system. back to top. skin functions in homeostasis include protection, regulation of body temperature, sensory reception, water balance, synthesis of vitamins and hormones, and absorption of materials. when body temperature falls, the sweat glands constrict and sweat production decreases.