Peroxidase is an enzyme found in many organisms, from plant to humans. The function of peroxidase is to break down hydrogen peroxide, which is a toxin produced as a byproduct when oxygen is produced during respiration. Myeloperoxidase is a protein found in neutrophils and catalyzes lipid peroxidation involved in immune defense. The overproduction of myeloperoxidase has been found to function as a mediator for tissue damage in inflammatory diseases. Identify two examples of environmental factors that may impact salivary peroxidase activity. Describe how each of the environmental factors would affect the reaction rate of the enzyme.
Predict the how researchers can use myeloperoxidase activity as oxidative stress biomarkers in patients with rheumatoid arthritis. Provide reasoning to justify your prediction.