Why are most mutations in cancer cells called 'passengers.'?

What allows cancer live at high mutation rate? Which mutations make it weaker? Is there a way to exploit its natural mechanisms to make it less evolvable? Harvard Associate Professor, Leonid Mirny, on clinical phenomena we can now explain using the balance between ‘drivers’ and ‘passengers’.

as the gila monster consumes the eggs or young of the desert cottontail and gambel's quail, thus its main food supply is only accessible for a restricted time duration every year. however, for this, the gila monsters exhibit three adaptations, which elevate their survival rate in the desert condition.  

first, is that they possess huge bodies, and can consume greater concentrations of food during a small period. secondly, they require to feed infrequently as they can accumulate fat in their tails. ultimately, their rate of metabolism is very low, so that they can burn their reservoirs of fat gradually.  

cells spend most of their time in interphase