The study of escherichia coli led researchers to new experimental designs for studying operons. which expiremental design did the scientist use?

D. Read the genome sequence to determine the quantity and organization of operons. 

The scientists used the technique to study operons in E. Coli by studying the genome sequence. This sequence would also tell the frequency of occurrence of operons in the sequence and where they are located and in which fashion are they organized. It is important to understand which genes are coupled up in the operon.