What is a major difference between skeletal muscle and cardiac muscle? what is a major difference between skeletal muscle and cardiac muscle? skeletal muscle is found embedded throughout the body in the walls of several systems (respiratory and organs (bladder; cardiac muscle is found only in the heart. skeletal muscle is under voluntary control; cardiac muscle is spontaneously active and involuntary. skeletal muscle is not stimulated by the nervous system; cardiac muscle is stimulated by the nervous system. skeletal muscle and cardiac muscle are both under voluntary control?