2. how do the effects of insulin resistance compound to decrease cellular responses to insulin?

Answer and explanation;

-The insulin receptor itself has decreased kinase activity leading to fewer binding sites for singling effectors to become activated.

Therefore; the signaling effectors are less likely to be activated.

-Additionally,, feedback inhibition decreases signaling effector binding to receptor.

-The lack of activation of these initial signaling effectors prevents any subsequent steps from happening.

-We can thus conclude this by saying that higher insulin concentrations are necessary to obtain the same level of signaling leading to physiological effects that would exist in someone without type-2 diabetes.

-Also the requirement for higher insulin concentration means that the cells that respond to insulin are resistant to its effect.

the answer would be d

ya the other dude is right