In a biological reaction involving an enzyme, what does not directly participate in the reaction?

the active site of an enzyme

the active site of the substrate

the inactive site of an enzyme

the reactant chemicals

Nephrons, the functional unit of kidneys, are responsible for formation of urine. the sentences describe situations that are the result of problems in the urine formation process. for the nephron shown below, match each situation to the step in the urine formation process where the problem lies.