The release of during a type i hypersensitivity reaction contributes to swelling. prostaglandins histamine leukotrienes both histamines and leukotrienes both proteases and prostaglandins

The answer is both histamines and leukotrienes.  It is an arrangement of undesirable responses delivered by the typical safe framework, including hypersensitivities and autoimmunity. They are normally alluded to as an over-response of the resistant framework and these responses might be harming, awkward, or once in a while lethal. Excessive touchiness responses require a pre-sharpened condition of the host.