why are the polio virus unable to reproduce if their DNA base sequence is different from the normal virus?

When the virus infects a cell, the RNA genome enters the cell and programs it to make new virus particles. These virus particles are released from the cell and go on to infect new cells. In humans, poliovirus is ingested, and replicates in cells of the gastrointestinal tract.Poliovirus, the prototypical picornavirus and causative agent of poliomyelitis, is a nonenveloped virus with a single-stranded RNA genome of positive polarity. The virion consists of an icosahedral protein shell, composed of four capsid proteins (VP1, VP2, VP3, and VP4), which encapsidates the RNA genome (1).RNA viruses generally have very high mutation rates compared to DNA viruses, because viral RNA polymerases lack the proofreading ability of DNA polymerases. The genetic diversity of RNA viruses is one reason why it is difficult to make effective vaccines against them.

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explanation:

scientists have discovered that hiv does not cause aids by the virus's direct effect on the host's immune cells, but rather through the cells' lethal influence on one another. researchers from the gladstone institutes have revealed that hiv does not cause aids by the virus's