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Biology, 10.05.2021 23:40 lauren9261
The MAP kinase pathway is activated by ligand binding to a transmembrane receptor, which switches Ras on via GEF (Guanine nucleotide Exchange Factor) that counteracts GAP (GTPase Activating Protein) activity. Ras-GTP in turn activates the downstream signaling intermediates (kinases), which are activated by sequential phosphorylation. Which drug CANNOT be used to target cancer cells that have elevated receptor activation
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