Why might the expression of a transgene be especially abnormal in vertebrates with larger average size of genes and amount of heterochromatin in their genomes?

position effect

Explanation:

Position effect refers to the consequences on the expression of a gene/transgene when it is inserted into a new genomic location, thereby explaining how transgene's behavior is affected by its genomic location. The differences in expression of the inserted gene/transgene are generally due to its proximity to regulatory sequences (e.g., enhancers). Species with larger genomes have many genes as well as long intergenic regions where heterochromatin may spread stochastically (randomly) in order to switch on/off the gene expression, thereby resulting in unstable phenotypes.

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