Biology, 30.05.2021 01:00 rosebebo7615
The enzyme dihydrofolate reductase (DHFR) normally resides in the cytosol, and it can be imported into mitochondria by appending a mitochondrial signal sequence. However, when this modified DHFR is incubated with methotrexate, which is a substrate analog that binds tightly to the active site, the modified DHFR is no longer imported. Propose an explanation for this finding.
Required:
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The enzyme dihydrofolate reductase (DHFR) normally resides in the cytosol, and it can be imported in...
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