What are the classifications of CYP Inhibition? Creative Bioarray evaluates drug candidates as direct, time-dependent or metabolism-dependent inhibitors by using human liver microsomes, recombinant CYP enzymes or human hepatocytes. Our design allows us to screen for inhibition due to the drug added to the test system, as well as inhibition due to metabolites formed during pre-incubation.

https://dda. creative-bioarray. com/cyp-inhibition. html

Inhibitors and noninhibitors classification models for five major CYP isoforms, namely 1A2, 2C9, 2C19, 2D6, and 3A4, based on a large data set of over 24,700 unique compounds with known CYP450 inhibition were developed

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