How does being hydrophobic affect protein folding?

The hydrophobic effect is considered to be the major driving force for the folding of globular proteins. It results in the burial of the hydrophobic residues in the core of the protein. It is exemplified by the fact that oil and water do not mix and was described well by G. S. Hartley in 1936 .

They create genetic variations

That is true tge cactus as a structural adaptation to its envirinment has it leaves reduced to spines. but this doesnt mean it cant produce food it produces food because of the presence of chlorophyll in its stem