Explain the difference between a dominant negative mutation and haploinsufficiency at the molecular level. An enzyme, encoded by gene A, converts substrate X into product Y. Individuals with a rare dominant mutation in gene A have severe neurological symptoms. If you could purify protein A from affected and unaffected individuals, how would you determine if the symptoms were caused by a dominant negative mutation versus haploinsufficiency. In your answer, explain your experimental results.

straight or amphibians are homeothermic to thermal

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air enters through the nose, moves through the nasal cavity, the pharynx, the larynx, enters the trachea, moves through the bronchi andbronchioles till the alveoli.

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these macromolecules could either be amino acids, proteins or nucleic acids. they are responsible for the chemical changes and reactions that affects largely the cell and its composition. take for instance the cytoplasm of the cell where these organelles are settled. these simple organelles are composed of macromolecules which ignites and catalyses different functions that enables cells, in macro-perspective in motion and metabolism. in intestines for example, metabolism happens and breaking down parts of a food to simpler compounds that are used and these nutrients delivered throughout the body and again broken down by into smaller components.