Some local anesthetics that are used to block nerve pain work by decreasing the permeability of sodium in the plasma membrane of the neuron. Explain the effect that this change in permeability would have on the generation of

This question lacks options, options are: A) Less action potentials are generated because sodium is needed to partially depolarize the neuron causing it to reach the threshold.B) More action potentials would be generated because sodium enters the neuron more quickly C)Fewer action potentials are generated because the neuron cannot be rose to the resting membrane potential D)Decreasing the permeability of sodium prevents the generation of action potentials because sodium cannot enter the cell to depolarize it. The correct answer is D.

Explanation:

Local anesthetics block the genesis and propagation of electrical impulses in electrically excitable tissues such as nervous tissue. When a nervous stimulus arrives, the depolarization of the membrane begins. The electric field generated activates the sodium channels (active state), which allows the passage of Na + ions, which en masse passes into the intracellular medium. Local anesthetics prevent the propagation of the nerve impulse by decreasing the permeability of the sodium channel, blocking the initial phase of the action potential, thus reducing the entry of Na + ion into the intracellular space. For this, local anesthetics must cross the nerve membrane, since their fundamental pharmacological action is carried out by binding to the receptor from the cytoplasmic side of it.

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