Help me pls ASAP

It's my first year of high school lol

What was dr. willem johan kolff’s first step in using the scientific process to invent the hemodialysis machine? he built the machine and tried it with various patients, collecting data about its effectiveness. when a patient’s kidneys failed, he wondered if it would be possible to perform kidney functions with an external machine. he researched and collected data about numerous patients who exhibited symptoms of kidney failure. he drew conclusions from studies of various symptoms of kidney failure, and drew a design for the ideal external blood-processing machine.

I’m stuck on this question cuz i’m stupid sksksksk

When you run, you begin to breathe heavier and faster. your heart beats more quickly, bringing more oxygen to your cells. which organ systems are working together here?