All of the following are epigenetic mechanisms, EXCEPT . changing gene expression by changing the nucleotide sequence through mutation changing gene expression by adding and removing methyl groups to DNA changing gene expression by the use of small noncoding RNAs changing gene expression by adding and removing chemical groups to histone proteins changing gene expression by the use of long noncoding RNAs

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the principles and empirical processes of discovery and demonstration considered characteristic of or necessary for scientific investigation, generally involving the observation of phenomena, the formulation of a hypothesis concerning the phenomena, experimentation to test the hypothesis, and development of a conclusion that confirms, rejects, or modifies the hypothesis.