In a watery environment polar amino acids want to have contact with

Polar amino acids tend to be hydrophilic, meaning that they bond to water. These are those that establish hydrogen bonds to water. They are considered polar because they have a R group that's hydrophilic. Because of this characteristic, in a protein they tend to a be a at the surface maintaining contact with the surrounding solutions. The most common polar amino acids are: arginine, lysine, glutamic acid, and aspartic acid.

Amutation is basically the change in the gene, caused by alteration of single based units in the dna, or the genes or chromosomes were rearranged in the dna