Cells from advanced malignant tumors often have very abnormal chromosomes as well as an abnormal number of chromosomes. what might explain the association between malignant tumors and chromosomal abnormalities?

The advanced malignant tumors are often associated with abnormal chromosomes and abnormal number of chromosome which results to the association between chromosomal abnormalities and malignant tumors. This association best explains with the reason that cell cycle checkpoints are not in place which cannot stop the cells with chromosome abnormalities.

Since a female is both xx chromosome and the male passes down the x chromosome, than the offspring would be female since a female is xx.