About half of the clinical cases of severe sore throat are due to streptococcus pyogenes, and most of the rest are due to viral infections. accurate and rapid diagnosis of a severe sore throat is important because untreated group a streptococcal infections can lead to

Untreated streptococcal infections caused by streptococcus pyogenes can lead to rheumatic fever, which is a serious inflammatory disease that affects the heart, kidneys, joints, and even the nervous system. Rheumatic fever can permanent damage the heart, and when that happens is known as rheumatic heart disease. It can also become chronic without treatment.

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