The first stage of alzheimer disease is characterized by:

In the first stages of Alzheimer’s disease, the patient affected may experience symptoms, such as memory loss of certain events. As the time passes, the patient may experience long-term memory loses, the patient may also revert into being a child. Patients who has been diagnose with Alzheimer’s Disease are commonly diagnosis with pneumonia, which may lead to their death. 

micro/nanoscale topography surface exhibits many prominent properties and is extensively employed in biomedical device, microfluidic device and energy device fabrication. additionally, the clinical applications of biomaterials can be largely expanded with of nanostructured surfaces.