What would happen to an enzyme if the temperature and ph change significantly beyond the enzyme is optimum level

When the temperature and the pH value of the surrounding is significantly beyond the optimum level, the enzyme would be DENATURED.

Denaturation occurs if the active site of the enzyme changes shapes, it can no longer bind into substrates therefore it cannot function anymore.

Usually when the temperature or pH increases, the enzyme won't denature at once. The active site slowly changes shape, decreasing the rate for chemical reactions. Denature is where until the active site completely changes that no more substrate can bind into.

Note that denature doesnt mean the enzyme dies, enzyme is not a living thing, even though it cannot function anymore.

Answer : romans built laws to manage the pollution which was lead by smoke produced by the factories.

they had the law tat factories that produces smoke cannot be built near residential buildings.

building of proper sewage system was done to ensure that the waste is carried away from the humans so that they do not get diseases from it.

also they built water systems to provide water in those areas which are drought prone.