Advantages and disadvantages of budding reproduction

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a neutral ph of 7 and normal organism temperature is needed for a certain enzyme to be effective.  

what would happen to the enzyme if the ph and/or temperature fluctuate greatly from the norm?  

a.the enzyme’s hydrogen bonds will break.  

b.the activation energy will increase.  

c.more product will be formed.

d.the ideal temperature and ph for the enzyme function will decrease.  

answer; i believe that the correct answer is(d) nondisjunction during meiosis;