The enzyme that catalyzes the production of acetyl coa is this enzyme is negatively regulated by in a high-energy charge situation.

1) pyruvate dehydrogenase: This is a complex regulatory enzyme that catalyse the production of acetyl coA from pyruvate in a process called pyruvate decarboxylation.

2) NADH: It is a potent allosteric inhibitors pyruvate dehydrogenase.

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