Pyruvate dehydrogenase is when the ratio of atp to adp (atp/adp) are high.

Inactive

Explanation:

Pyruvate dehydrogenase controls the production of acetyl CoA.  This conversion is regulated by regulators like ADP, ATP, AMP and NADH. While ADP and AMP are regulators that enhances the activity of the Pyruvate dehydrogenase enzyme, regulators like ATP and NADH reduces the activity of the Pyruvate dehydrogenase enzyme. Thus, when the ratio of ATP to ADP is high then the inhibitory regulator i.e ATP is in large amount than the ADP. Hence, ATP reduces the activity of enzyme Pyruvate dehydrogenase and makes it inactive.

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