In aggressive forms of breast cancer, the gene encoding a protein called stathmin is overexpressed. inhibiting expression of the stathmin gene arrests cells in m phase and is being investigated as an alternative therapy for treating cancer. what additional genes could be therapeutic targets that, when inactivated, would arrest cancerous cells in g1 phase?

Stathmin protein plays a crucial role in the regulation of the microtubule cytoskeleton. The aggressive form of breast cancer is caused due to the overexpression of stathmin. The genes that code for cyclin complexes are arrested in the G1 phase.

The G1-phase arrest is a type of mechanism in which cells undergo repair mechanisms or follow the apoptotic route. The type D cyclins are responsible for the activation of cyclin-dependent kinases. These complexes are responsible for the progression of cells through G1 to S phases.

The stathmin overexpression leads to breast cancer. The inhibition of the gene is done by:

Therefore, to know more about the cell arrest and cell cycle, refer to the following link:

link

Inactivating genes that code for cyclin proteins (in this case cyclins -type D) would arrest a cell in G1 phase. The type D cyclins are responsible for activating cyclin-dependent-kinases 4 and 6 responsible for the progression of a cell through the G1 phase to S phase.

americans began to notice growing differences between the northern and southern sections of the country. there were more people living in cities in the north, which made it more urban. more people lived on farms in the south, which made it more rural. while many people were farmers in the northern states, there were now other ways to make a living, such as working in mechanical cotton gins factories manufacturing cloth, tools and other goods. people in the north supported high tariffs on goods imported from europe because the extra cost encouraged people to “buy american” instead. in the southern states, planters did not like tariffs because they sold most of their production to europe and bought their tools from there as well. southerners believed the protective tariff was something that only northern factory owners keep their profits high. so the southern politicians came up with an idea. they would opt out. they would simply ignore the protective tariff. it was ‘null and void’ in south carolina. the state would not collect the taxes on goods imported into south carolina, no matter what the president said they had to do. this decision led to the nullification crisis.

relative humidity, temperature and dew point -- are bound together in the mathematical relationship below. relative humidity changes when temperatures change. because warm air can hold more water vapor than cool air, relative humidity falls when the temperature rises if no moisture is added to the air. so i would say a