Colchicine is a drug that is used in plant breeding to create polyploids. it blocks the assembly of microtubules. if dividing cells are treated with colchicine, at what stage of mitosis would you predict the arrest would occur? metaphase telophase g1 of interphase prophase late anaphase

The answer is prophase. In prophase the mitotic spindle forms and the chromosomes condense. This is in preparation for metaphase where spindle fibers are then formed and attached to the kinetochores of the chromosome’s centromere awaiting to pull the chromosomes sister chromatids (in mitosis) of sister chromosome (in meiosis) to opposite poles. The spindle fibers are composed of microtubules hence interference of microtubule assembly by the colchicine result to non-formation of the spindle. The cell mitosis cannot, therefore, progress past metaphase stage.

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