Annabelle has been a heavy drinker for decades. she recently has been having problems with her memory, confusion, unintelligible speech, and loss of muscle coordination. these symptoms are likely the result of

The symptoms described are most likely the result of Wernicke-Korsakoff syndrome (WKS). This is a kind of brain disorder that is caused by the deficienc of vitamin B1, or thiamine. This is usually seen in alcoholics. 

Wernicke encephalopathy and Korsakoff syndrome are two separate conditions. Korsakoff syndrome usually occurs right after Wernicke encephalopathy symptoms die down in alcoholic patients. 

Alcohol consumption should be prevented as soon as it is diagnosed to prevent further brain damage.