Aframeshift mutation that occurs very early in a protein sequence would have what effect on the protein's structure? see section 16.4 (page 344) . view available hint(s) a frameshift mutation that occurs very early in a protein sequence would have what effect on the protein's structure? see section 16.4 (page 344) . protein structure would remain unchanged. the primary structure would remain unchanged, but the secondary and tertiary structures would be altered. the primary structure would be altered, but secondary and tertiary structures would remain unchanged. primary, secondary, and tertiary structures would be altered.